Solid-phase extraction is the simple method with digital chromatography compounding either bind or flow through. With solid-phase extraction, many samples can be analyzed almost automated in parallel, but the process may take more time.
Due to its high selectivity, recovery, and reproducibility, SPE methods are widely used for desalting, solvent exchange, sample preservation, and storage.
Compared with the liquid-liquid extraction, the advantages of solid-phase extraction is easy to see. It improves throughput in parallel vs. serial processing, as while as decreases organic solvent usage and waste. It achieves higher and more repeatable recoveries, cleaner extracts from contamination and solvent impurities. The choices of SPE phase and solvent mixtures are always various.
Common applications of solid-phase extraction can be sample cleanup, such as in pharmacokinetic studies, dissolution testing, isolate analytes from complex matrices, such as urine, plasma. It works perfectly but only removing major interferences, but also eliminating late-eluters for the isocratic analysis.
SPE is a reliable method to enrich trace in the environmental analysis, the pharmaceutical and agrochemical applications. It is also practiced widely in processes of desalting, solvent exchange and sample preserve.
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