To select the appropriate SPE cartridge, we normally consider it from two aspects: the selection of adsorbent and specification of the cartridge. The use of appropriate adsorbent can achieve good separation between interfering substance and target component, and also meet the requirement of recovery. However, the mass of chemical compound which can be adsorbed by the adsorbent is limited, once the mass of the sample is too large, there can be overload which happens in the SPE cartridge, and therefore makes the target component directly go through the cartridge without being reserved.
Basically, we can select the adsorbent according to the properties of the target component and the substance. Moreover, for the concrete examples, we can also select the adsorbent which is based on the principle of “distinguish the target component and the main interferent”.
After selecting the appropriate adsorbent, we need to select the corresponding specification of the cartridge according to the volume of sample which needs to be determined. Because the mass of chemical compound which can be adsorbed by the adsorbent in SPE cartridge is limited, once the value exceeds it, the target component will not be reserved effectively. As a result, it is necessary to select the appropriate specification of SPE cartridge.
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